For example, I might work at a R&D company working on some kind of new magic technology. All of the R&D work happens on the disconnected LAN (call it R-NET) and that's our daily driver. All the computers have software on them to prevent USB drives and other removable media from being plugged in, and no wireless anything, and if I have to move data onto the R-NET from the internet, there's a designated security admin person who does the move. They do it with a physical drive, sneakernetting the data between the networks.
Their process is to get the data, scan with every kind tool known and toss out certain prohibited files (executables, scripts etc.)
If you need an executable or script on the R-NET, you go through another procedure that does a full security audit on that software, and only once it's approved and added to a special list of installable things can it be put on your machine.
Going from the R-NET to the Internet requires a reverse of the process, but everything getting moved out gets reviewed, every document, piece of data, etc. to make sure it doesn't contain anything that shouldn't be sent out.
Everything on R-NET is logged. Everything, log ins, log outs, what software you opened, what libraries that software used, everything.
There might be a security team who monitors the R-NET and the moment they see something suspicious they have a "kill switch" to disable the network and all the machines that are one it until the problem is sorted out.
It sounds extreme, and it is, but it can be reasonably effective. Some places even have different networks for different projects to provide further isolation.