If you read the PLOS One acceptance criteria:
http://www.plosone.org/static/publication
you'll notice that scientific merit doesn't show up in there. The official policy is that if the methods and analysis are sound, then it will be accepted regardless of how irrelevant the actual study is. This is well known in academia and has resulted in a generally negative opinion of the journal among publishing researchers.
edit: I'd also like to point out that this isn't the case for all PLOS publications.