A while before I had installed OpenBSD on an old box to play with. I recalled seeing something about a transparent bridge setup, so I got the idea of putting a transparent bridge with greylisting in front of the mail server. So I grabbed a slow cast off desktop, slapped an extra NIC in it, got it configured so I thought it would work, and put it in place. A few tweaks later and the load was off the mail server and it began responding to legitimate requests and clearing out its queue.
From idea to working solution took about 4 hours, including scrounging up parts, installing, and everything. I'm sure something similar could have been done with another OS, but what level of expertise would it have required? I was pretty much an OpenBSD newbie then, doing things I'd never even played with before, and that stuff just worked.
http://www.skeptech.org/blog/2013/01/13/unscrewed-a-story-ab...