When running OS X virtualized inside VMWare Fusion (which does not have hardware accelerated video drivers for the guest), Mavericks was very usable. Yosemite dropped to 2fps (measured using Quartz Debug tools).
I had to use Quartz Debug (available in the Graphics Debug Tools here [1]) to disable beam sync to make it usable again. In VMWare, this takes me from 2fps to around 50fps for basic operations like dragging a window around and typing.
I've observed noticeable improvements disabling Beam Sync in a native environment as well. Unfortunately, I've found no way to do it without leaving Quartz Debug open. Quartz Debug also has an FPS meter in the menu bar under "Window -> FrameMeter". My framerate when dragging a large window in Yosemite with "Beam Sync: Automatic" is around 40fps. With "Beam Sync: Disable" it's almost a steady 60fps.
A stable test in System Preferences for me is the Dock settings.