* GMOs tend to promote monoculture and pesticide use.
* Studies have shown that the same developments that make GMOs more insect resistant can also make them more difficult to digest.
* When it comes to animals, GMOs tend to have much poorer quality of life and tend to be completely incapable of surviving without constant support (chickens who can't stand on their own, cows who can't go more than 48 hours without milking, etc).
* GMOs almost never focus on the true value of a food item, but rather the sell value. A food that looks nutritious is more valuable than one that actually is and GMOs make it easier to create that false association (deep red tomatos that taste like wall paper glue, etc).
It's important to note that all of these things are really a byproduct of industrial agriculture, but many people associate them more directly with GMOs. I think the development of GMOs is a completely normal part of our agriculture and has been for thousands of years, we just need to make sure we're responsible about it.