Good News You May Have Missed in 2014
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[1] http://articles.economictimes.indiatimes.com/2013-06-23/news...
http://www.wsj.com/news/articles/SB1000142405270230344420457...
http://www.iom.edu/Reports/2012/Facing-the-Reality-of-Drug-R...
The fact that the regimen is shorter will hopefully mean higher completion rates: a big issue at the moment as the treatment can take up to 2 years leading many patients to take incomplete courses (and of course this fuels drug resistance). In Australia we're lucky enough to have the resources to provide free treatment with mandatory monitoring by health care workers (to enforce the full course is taken), but in India, PNG etc they desperately need a cheaper and more practical solution.
Edit to add: hopefully new drugs will also help those with sensitivity to the current antibiotics. They have some pretty harsh side effects, e.g. drug-induced hepatitis is a common problem which means many patients can't tolerate the preferred regimen.
http://www.who.int/tb/challenges/mdr/en/
In India, in particular, anyone can buy antibiotics, and they do, whether they need them or not. This problem should probably be addressed before we create a problem that we can't solve.
That still leaves the nasty issue of what to do with the large number of people who have contracted a highly contagious and drug-resistant / incurable disease.
As discussed: TB currently takes a long time to fully treat. A lot of patients can't afford a full course of the recommended combination of drugs. Even if they can, and are getting their drugs from official channels, they need to be monitored regularly (sometimes daily) to ensure proper treatment. The resources to do this monitoring simply don't exist in India (and many other countries). Thus, even if you could stop all unofficial access to antibiotics (impossible in practice), there is simply not enough funding to ensure every patient is properly treated.
This is why a shorter regimen is a key breakthrough. It makes proper treatment much more accessible (the big issue), while also reducing the discipline needed to complete a course (a small bonus).
But to prevent future problems, people need to stop using antibiotics as a cure all. It is particularly bad in India since patients there can aggressively demand antibiotics from hospitals and doctors.
I get it, some people have a bleeding heart and want to save everyone, everywhere, at all times; but what happens when the planet is the equivalent of a cat hoarder's house because we could never say no and we could never implement policy to limit population growth because the wealthy inherently gain from unregulated population growth?
The upshot is that as countries get richer, fertility rates decrease. Allowing these poorer countries to lead better lives will paradoxically lower the population increase. If you look at the western world, negating immigration, many countries have a shrinking population.
The more pressing problem of the future, ironically, will be under population - at least if you consider the economic impact and our way of life. Our economy right now is built on so much growth and young labor. What happens without poor countries and when more people are retired than working?
[0]http://annualletter.gatesfoundation.org/#myth-three=§ion...
Even with immigration, Germany has a slightly negative population growth rate. And the United States grew by only 0.77% in a year. Again, that's with immigration.
https://www.cia.gov/library/publications/the-world-factbook/...
There's a conversation to be had about the future of non-renewable resources and the preservation of renewable ones, but the population growth fear-mongering from the likes of Dan Brown is deeply silly and not based on the whole truth.
http://www.scientificamerican.com/article/world-population-w...
Vaccines without sex education and birth control support programs are extremely irresponsible. We need both, just one is trading off a short term problem for a bigger long term problem.
Are you sure there is no correlation between mortality and fertility rates? Assuming there is (which lots of evidence points to) there isn't actually any problem.
His statement is perfectly true if say rates dropped from 5 to 4. That still causes a growing population, but the growth rates are decreasing. Once a country gets rich enough, you usually see fertility rates drop below SRF.
In fact, in Europe for example it's around 1.6, while you need roughly 2.1 or so children per woman to sustain population levels.
http://www.scientificamerican.com/article/world-population-w...
But anyways, if we want to get around to a sustainable post-scarcity futuristic utopia, we need a global population of economically developed and educated people with replacement-level fertility. And when childhood mortality goes down, parents have an incentive to concentrate their investments (both economic and educational) into fewer children. Those children will be more successful, have better access and education about contraception, and won't need to have plenty of children to provide manual labor on their farm.
Anyways, that's how it's supposed to work, and has worked many times in recent history. I put less stock than others in the extrapolated results from the recent UN Africa study.
> I get it, some people have a bleeding heart and want to save everyone, everywhere, at all times; but what happens when the planet is the equivalent of a cat hoarder's house because we could never say no and we could never implement policy to limit population growth because the wealthy inherently gain from unregulated population growth?
Some of the minds saved can one day solve these and other problems, pushing the envelope of human knowledge.
As an example: any heat engine is limited in its efficiency by Carnot's Law. You can apply all the electronic smarts to it you want, but the best you'll get in efficiency improvements is a closer approximation of the theoretical maximum.
You can phase-shift and use different technologies -- hybrid vehicle drives allow for greater engine efficiencies (constant power) and energy recover (regenerative braking), but that's fairly minimal -- the complexity of a Prius and a comparably efficient high-efficiency diesel is great.
There are other issues in expanding systems beyond certain scales -- even if you've got genius minds out there untapped, how do you 1) train and educate them, 2) find them, and 3) incorporate and utilize their advances -- in all the other noise.
I don't see a huge win here.
Why? Because it's economically smart to have children.
In a labor-intensive economy, you can generate more income in the family with more children.
And in a poor subsistence economy, there is no surplus wealth being generated to go to the state for redistribution and another thing I'll get to in a minute. This means that institutionally-provided social security is often non-existent (no pensions, no insurance, no universal healthcare, no benefits, food stamps etc). So instead of institutions, these services are provided by the community, i.e. children. If you have 5 kids, there's a much better chance of someone taking care of you at old age, or when you're sick, than if you have few or no kids.
You have more kids because there is a higher chance of death. Child mortality under five is absolutely STAGGERING. I literally think about this every week and wonder why we can't get the news to report on it on a weekly basis. The number is about 17 thousand per day. Try putting that into perspective. That's more than 5 times 9/11 per day, or 50% the death-rate in World War 2 year in year out. At these rates, it makes sense to have more children, parents actually expect not all their children to last.
When you take death and sickness out of a community however, there is much more chance of economic growth. There are loads of UN reports on how mortality and sickness affects education, employment, parenting, productivity etc. In short, if you improve these things significantly in a country, 10-20 years later you see millions of extra people pour into the middle class.
And what happens then? The truth is that it's economically disadvantageous to have children in a wealthy society. Children cost (way) more money than they generate. Wealthy societies have child-labor laws (well, every country does, but they're enforced more strictly), as well as laws that require all children to go to school. Standards of living in a wealthy society requires loads of expenses on children, and price levels aren't low either. And lastly we see that in wealthy societies that there is more wealth-surplus, leading to cultures that have the time and literally the money to explore non-economic interests, like the arts, and this often goes hand in hand with less time spent on simply surviving and taking care of family members, in fact leading to sharply reduced birthrates as new generations grow up with a bigger interest in traveling than raising a family. (extensive traveling for recreation being something almost only possible in wealthy societies with a wealth surplus, i.e. the minimum amount of work you need to do just to survive is something like 30% instead of 90%, so if you spend 60% of your time working you have a large wealth surplus and a lot of free time).
In short, having 10 children is the 'worst idea ever' for most parents both economically and culturally the richer a country gets.
What does this all mean? Well, if you believe me, we've established that it makes sense to have lots of children in a poor country, and very few in a rich country, which is easily seen in empirical data. (it's not a cultural thing, most western countries with low birthrates had very high birthrates before they became wealthy post industrial revolution). And we've also established that mortality and sickness are huge inhibitors of economic growth.
Lastly, I'd say that a richer society with less mortality and sickness is more stable, better educated, has better funded institutions, which means natural family planning (like contraception and sex education in best case, or authoritarian China-style 1-child policies in worst case) should also be much more effective.
In other words, in the long run, reducing death rates is actually likely to decrease the size of the population, with of course the added benefit that it's freaking awesome to save lives that every living person deserves to have. After all, none of us would volunteer to die just to be able to 'sustain the planet with a lower population'! :) But I tried to ignore this point for argument's sake.
The corollary to this story is that a wealthier society consumes much more, which is less sustainable. (e.g. 500 million people in China/India who join the middle class and turn to 'basic' items like toilet paper is like adding another Europe or US. It's insane.) The fun and optimistic corollary to that is adding 500 million educated brains, who knows how many nobel prize winners will be among them providing the solutions we need :)
However, it's not like we couldn't cure hepatitis C before, we could, but just not very well.
The old regimen was interferon + ribavirin. You had to take it for months and months and the interferon makes you feel like you have the flu (it also put the patient at risk of depression and suicide). The cure rate was ~50%.
With the new drugs you don't need to get interferon injections anymore. You just pop one pill a day and 12 weeks later there is a 95%+ likelihood that you've been cured of HCV.
It's a HUGE medical advance.
The company who makes the drug is offering it a very low price to developing countries so the impact will be worldwide.
I'm sure that's a not insignificant amount of money for Egypt, but it's less than 1% of the price charged in the US.
[1]http://www.hepmag.com/articles/egypt_gets_sovaldi_for_cheap_...
Solvadi could be paid for with monthly payments, say, 90% of the average price of conventional Hepatitis C treatment. Once the total payments add up to the price of Solvadi, they stop.
The patient gets cured right away. The healthcare system sees a 10% savings instead of a $90,000 bill. Gilead gets a smoothed-out income stream that helps to insulate it from the feast-or-famine cycle.
What's more, this places a built-in limit on the price of the drug. If Gilead sets the price too high, then the monthly payments never add up.
In a system where the patient could switch insurers, the monthly payments would have to be imposed on the new insurer. Otherwise, we're back to the US game-theory standoff.
The interesting thing is that Sovaldi is not more expensive than earlier therapies (last generation therapies were around $85K). The issue is that Sovaldi is so good that everyone wants to take it now, where before, very few patients were willing to put up with the old therapies.
There's a bit of a dark side, though, in that this miraculous cure's creator was bid up to billions of dollars, and the cure is sold to American health insurance for ~$85k a course, which is out of reach for most people without health insurance.
Of course, if you limit the upside on the home runs, you may find yourself with fewer batters in the pharmaceutical industry. I'd personally prefer if governments directly funded research, or even better, offered X-prize style contests, rather than granting patents on drugs.
But none of that diminishes what a remarkable advance this is for millions of Americans.
Considering most pharmaceutical companies have profit margins of ~30%, you'd need an x-prize of $10-$15B to equal their current "prize". The NIH total budget is under $40B.
That would likely mean fewer baldness treatments, which I'm fine with. What's unclear is whether we'd get a more socially optimal investment level for DALY improvements. I tend to think we would.
What you're suggesting is limiting the upside for investment. How do you think investors (the ones giving money to develop a drug) would react if you told them that the best they can do is a 2x return on their money when before they could get a 5-15x return?
What incentive would any of those labs have to spend their budgets efficiently?
[1]: https://www.nice.org.uk/guidance/indevelopment/gid-tag445
[1]http://www.forbes.com/sites/theapothecary/2014/08/18/uk-says...
An American insurer would rather put you on the older treatment and make your life so miserable that you switch to another insurance company at the next open enrollment. It makes no sense in the aggregate, but it makes sense for any one insurer.
No insurer wants to have the most generous policy, because it will just attract Hepatitis C patients from other insurers, hitting them with the up-front costs. However, they would not get all the delayed savings, because the patients could switch to a different insurer after they were cured.
The only way to break the game-theory logjam is to force the drug to be covered nationwide. Then, all the insurers pay the up-front cost, and on average, all of them reap the savings.
The thing is, that's not happening at all. Nearly all US insurers are covering the new therapies. There are a couple that are holding out and only doing individual approvals.
You have to remember that private insurance competes on coverage, particularly for the insurance purchased by large employers.
Your comments about the NHS having a different viewpoint is correct. Since the NHS looks at total societal costs, they can reap the benefit of any immediate costs.
So what are all the news articles about? A problem that is only hypothetical? The reporters don't seem to have a hard time finding cases of Hepatitis C patients who have been denied:
http://kaiserhealthnews.org/news/most-illinois-medicaid-pati...
http://www.npr.org/blogs/health/2014/10/28/359553282/insurer...
Then there's the fact that AbbVie and Merck are coming into the market soon with their own Hepatitis C drugs that also have 90% cure rates. It seems hard to believe that either of these companies will come in significantly below the price of Sovaldi, but that's what the insurance companies are hoping for.
I should have be clearer as I was referring to private insurers. Yes, a few of them (Express Scripts is one) are saying no, initially, but appeals are getting approved.
I actually work in the HCV field and saw some data the other day that showed the vast majority of plans are reimbursing for Sovaldi. It was pretty surprising to me.
And yes, we'll have to see what Abbvie and Merck do. Rumor is they won't be competing on price although the insurance companies are hoping they do.
Why? If you apply game theory, one of the three will try to defect and undercut the other two.
Because they're playing a repeating game. AbbVie and Merck are big pharma companies. They don't particularly want to get into a price war.
It would be different if a small biotech firm were coming in. They might not get a second shot at it for a long time, so they are much more likely to undercut on price.
Also, three is a low number. Defection is more likely when the number of players goes up.
Of course, they're not going to come in dollar-for-dollar identical to the pricing of Sovaldi and Harvoni. However, the insurance companies seem to be hoping for some really sharp drops in price, which are less likely.
The root cause is that those are areas with very high levels of tribal paranoia, religious fundamentalism, and outright violence.
The outbreak was contained after 21 confirmed infections plus another 23 suspected. The Chinese public health system mobilized 1000 health workers, spent $26 million, and vaccinated 44 million people.
If we can't get rid of polio in Pakistan and Afghanistan, then this will just keep happening.
NEJM editorial: http://www.nejm.org/doi/full/10.1056/NEJMe1311591
1) http://www.amazon.com/Its-Not-News-Fark-Media/dp/1592403662/
Protip: If you abandon your subscription in last stage of the cart and come back later, it knocks 50% off the price. It did for me anyway.
Pick the fantasy you're most comfortable with.
I learn more from reading the 2 front page summaries (news + business) in the Economist than from all my internet daily news reading.
For the most part, I simply haven't missed it. Events worthy of my attention (i.e. that will change my behavior) tend to bubble up through more specialized news sources (like Ars Technica or my Twitter feed) anyway.
That said, I have found NextDraft (http://nextdraft.com/) very useful.
Just wanted to let you know you have a 'bug' on the 'contact us' section, I assume only for iOS devices. It comes up with a gray area blocking the forms, with the text out of place.
Great site, and it's good you're giving so much back to the world to fight worthy causes.
I've cold emailed a lot of well known people before and most of them responded. I guess it was 'positivity' that skewed my thoughts. But, your right, a Lotto chance of Bill Gates coming on here.
What effects do these trends have on poverty and food insecurity?
Not a massive problem in this case but worrying.
You are saying we shouldn't have to pay taxes so the state can plan and execute vaccine campaigns and offer chronic disease treatment without cost to the patients that need it?
This is the case in Brazil (for instance http://en.wikipedia.org/wiki/HIV/AIDS_in_Brazil) and I happily pay my due to make it happen.
Not all tax money is actually put to good use, but the greater part is and I certainly wouldn't advocate against that.
Of course some countries have weird priorities IMO (yes, US) and may not share this view.
Good News! You May Have Missed 2014!
Sources: http://www.scientificamerican.com/article/premature-deaths-m... http://www.who.int/features/factfiles/malaria/en/
Milder winters expand the range of disease-carrying insects, increase risks of wars or famine with less water, mass migrations leading to political instability, more extreme weather events like draughts and flooding leading to failed crops and other natural catastrophes...
Meanwhile much of the WHO estimate is for people dying due to heat exposure. Easy to quantify, important to know - but nowhere near the full picture.
Malaria is unlikely to get much WORSE than it is now. But if you think that global warming has a chance to cause catastrophic damage, two or three orders of magnitude more than malaria is causing today, then you should estimate the probability that you can impact global warming and do the EV calculation.
How can the very lack of evidence and data logically support a claim that any estimate is either too low or too high with any "certainty"?
As another reply has already noted, that seems incorrect even for just one disease that the Gates Foundation is working on eradicating. That would be even more incorrect with reference to "any" disease, meaning even diseases that are in the top five worldwide as causes of death. Most people will survive global climate change by adjusting to local weather, the same as most people long have done throughout human history. People in the Netherlands have already figured out how to live below sea level, people here in Minnesota have already figured out how to live in a place with wild annual extremes of temperature, and so on.
1. http://www.ted.com/talks/bill_gates?language=en
2. http://www.rollingstone.com/culture/news/bill-gates-the-roll...
3. http://www.gatesfoundation.org/Who-We-Are/General-Informatio...
I have the sneaky (unscientific) suspicion that whatever drastic measures we would inevitably have to take to curb CO2 emissions is going to open its own can of worms. The footprint of human activity is simply that large.
This is the most important graph of this century:
http://fund-balance.com/wp-content/uploads/2014/04/Solar-Mod...
It was made in 2012 when solar costs were $1 per watt. The Chinese solar industry has gotten the price down below .50 per watt this year.
Solar PV panels are going beyond grid parity. 70% of the power generated by a coal plant is wasted in the transmission line before it reaches your home. The data has spoken and solar has won.
I believe this is the development that will let us avoid run away catastrophic warming.
Humans are rational actors when presented with cost-based options. Politics, biases and ideology fall away when looking at price.
And ramping up and scaling production of high demand items and bringing cost down in the process is where modern capitalism shines ie. the relentless deflation in consumer technology (pcs, tablets, flat panel displays)
In order to avoid catastrophic warming we have to reduce emissions by something like 80% by 2050. That seemed a pipe dream before cheap solar panels, now it feels inevitable to me.
Cheap solar is the energy miracle Bill has been waiting for. I hope that he includes it in his 2015 post when solar is $.25-.40 per watt.
Really? Explain Verblen Goods[1].
Fact is, while price drops do help businesses, there are other complications with home solar - utility companies need to simplify net metering so I don't have to either go off-grid or calculate exactingly to prevent wasted collection. Install costs are also high. Furthermore, there are many houses with many natural gas appliances that reduce the benefits (you're still paying utilities for gas and likely a lot in winter).
(ok, ok, this is a bit trollish, but my point stands: the world is getting better and the sky is not falling -- deal with it)
Everybody here already knows this of course. ;)
Non-contrarian: "Saving kids is good!"
First-order contrarian: "Malthusianism! Overpopulation! Blargh!"
Second-order contrarian: "Education leads to reduced population. People have fewer kids when they know child death is very rare."
Third-order contrarian: "Population collapse! End of growth! Blargh!"
Fourth-order contrarian: "We've dealt with worse and survived. Maybe space colonization will provide a positive impetus for population growth and a new engine for economic growth."