My desktop is where I spend the most time, yet it was the last remaining device I use where there were visible, ugly, distracting pixels everywhere. Now I never see pixels in my daily life, and reading and writing on my desktop have become significantly more pleasant. I highly recommend switching to a high-DPI monitor for anyone who spends much time on the computer (which is probably almost everyone here).
Oh, most software works just fine once I manually set the DPI in KDE's system settings. Upgrading to Plasma 5, the only software I use that isn't scaled properly is Chrome. Apparently they're working on it, but I only use Chrome for Netflix, and it's not too bad having tiny browser tabs for that one use.