Stem cells: The black box of reprogramming

> "an international collaboration audaciously called Project Grandiose"

Nice to see audacity in hard science on in a while isn't it???!!

> "transcriptomic epigenomic and proteomic data sets"

So your 'big data' startup has a few petabytes? lel.

> "Early transcriptional events, driven by high levels of reprogramming transcription factor expression, are associated with widespread loss of histone H3 lysine 27 ( H3K27me) trimethylation, representing a general opening of the chromatin state "

IANASCBC ( I am not a stem-cell biochemist ) but the state of chromatin corresponds with how readily certain genes are accessed, facilitating transcription ... and ultimately "what happens in the cell"

project website: http://www.stemformatics.org/