Alternative perspective - Recognize any time you use a cloud provider, you need to be aware that not only are the nodes ephemeral, but the zone/data center you are deploying on may go down as well.
Plan for your server to go down at any time, and, if you have actual $$$ in play, also plan for the zone to go down.
Amazon encourages this thinking by having very low-latency links between AZ (Availability Zones) - and they also recommend deploying in two geographical regions should a regional disaster occur.