It may be a bit different in sports, where handedness matters more directly. At least in fencing, a right-hander going against a left-hander is a very different situation than two people of the same handedness competing, and because right-handers are such a majority, lefties have loads of time to practice exploiting the lefty-v-righty special case. Actually one of the really interesting things is watching lefties against other lefties, because neither tends to be used to what for righties is the 'normal' orientation to the opponent.