While I understand the sentiment, I only used a single resume for all of my applications this past fall. But I think the reason it worked is that I knew what positions I wanted to apply for and they were all similar(ish). So my resume matched all of them.

I did find that when I was applying to the bigger SV companies (and Seattle), I wasn't necessarily applying for a specific position, so even if I had wanted to tailor it, it would have been more of a challenge. That's just my experience though. I do believe that if I was going for a very specific position, I would definitely spend the extra time to make sure it was perfect.