Reading this, I'm reminded of Kary Mullis, inventor of PCR (polymerase chain reaction). PCR is widely considered to be the most important discovery of modern biology, ushering a new era of scientific research after he invented it in the 1980s. He won a nobel prize for it.

Kary was a bit off though (in this case due to intense drug usage, I think). Afterwards, he went on to deny that HIV is the cause of AIDS, tried to discredit global warming, and began believing in astrology and magic.

In the end, its possible that a little bit of insanity is a good thing; that it can help someone make a profound discovery that no one else could see. Too much is obviously detrimental, however.