It depends on how you define "science". If construed broadly, to mean using reason and evidence-based approaches to evaluating claims, then science tells us a lot. Is it better for the nations of Europe to strive to live in mutual cooperation with each other? Or should they instead perpetually wage war against each other, at any cost? Imagine posing that question to both pre- and post-enlightenment peoples and contrasting the responses.
>Or say, if we can somehow determine our universe is a simulation, then it would be nice to know what the "basement universe" that is running this universe is. Of course, it's possible such knowledge will remain forever inaccessible, in which case, we'll probably need novels and philosophy to deal with the voids left in our hungering minds.
Science is presently the best cure for the voids that exist today. You'll need a really good argument for switching to novels and philosophy for the voids of the future.