Ask HN: How do you use web analytics effectively for niche B2B sites?

There's a bounty of info out there on using Google Analytics and its ilk for web apps, e-commerce sites and larger consumer-oriented sites... But my dilemma is different. I have owned a boutique B2B business for over a decade, providing technical, design and end-user training on a (wildly popular in the enterprise) popular business software tool. We have a decent mailing list we engage with several times a month with a low attrition rate. But we're struggling with identifying how best to use analytics to help answer the questions that we don't know to ask.

So what questions do you ask of your preferred analytics, and how do you use the tool to answer them?