Sure, the first thing you'll hear to that issue is "Do you really need to have that many options/paths/data?". And granted, quite often this is applicable, although not always in the same way (hiding rarely used options vs. eliminating them, i.e. "advanced options" vs. "only one friggin mouse button").
But often enough, presenting lots of data and hierarchies is the whole point of an app, especially when it gets more about enterprise systems than "what pancakes do my friends like" web 2.0 frippery. And that's where the ideas coming from ad design and typography kinda fail.
Which is why people like Tufte are so respected, as they go beyond this. If I recall correctly, in the initial review of the iPhone Tufte recommended against even the minimal margins of the photo gallery, removing white space for a better experience. And yes, knowing the rules before you break them might be a part of that...
If you don't do this as your full-time job, I'd very much recommend going for "usable" instead of "gorgeous". The latter is very much a 80/20 deal, where you spend insane amounts of time, asking co-workers and A/B tests just to get that final ratio or pixel size right. Whereas most of your customers still have Nappa Valley as a background picture behind their copy of IE9...
I don't really miss under construction signs and rotating skulls, but I do have the slight feeling that a lot of what designers are doing will be like early 20th century typography in a few years, where even some of its major proponents aren't quite sure about it anymore...