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Both Cruz and Lee are assumed to be in contention for 2016. Neither can reasonably expect the nomination, but both could, with a decent showing in the early primaries, end up with the VP nod. They are very unlikely to buck the party at such a sensitive time (the optics of doing so right before McConnell takes over as majority leader are bad).

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But they did buck the party. This was a mostly dem-supported bill.

http://www.senate.gov/legislative/LIS/roll_call_lists/roll_c...

Note: I deleted my original post because I mistakenly said Paul had voted for the bill. Paul voted with the establishment republicans (McConnell, etc) against (i.e. to keep the NSA as-is)

Edit: Also, Cruz bucks the Republican leadership all the time. That's his thing and they hate him for it. He was the main force behind the government shutdown.

I think the key part here is that they're strongly associated with the Tea Party enough that they're not worried about a challenge from the right in the next election cycle. I doubt we'll see very many others feel comfortable straying out of the fold unless it's something which is really important to voters back home.

Paul explained why: http://www.paul.senate.gov/?p=press_release&id=1244

TL;DR: Paul voted against this act because voting for it means renewing the PATRIOT Act for another couple of years.

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