However community isn't big as that of Flask and has low bus factor.
Other alternative is Django REST Framework[0]. It's also well documented and get the work done. However code base is large compared to Tornado. Advantage is, it has a bigger community support and it's easy to find a developer.
I know that SurveyMonkey also uses the pyramid+nginx setup.
Edit: Pyramid Documentation: http://docs.pylonsproject.org/en/latest/docs/pyramid.html#py...
It's new, not fully baked yet, and yet it is amazingly powerful and simple to use.
I've deployed many small websites using flask+uwsgi+nginx before, but for a high-volume API, there seem to be a number of "fragile" aspects to this, e.g. processes and threads settings, since WSGI is synchronous.
If I may ask, what's usually the weakest link in this setup, and what's the best way to monitor for problems and scale appropriately and intelligently as users grow? For example, let's say I set processes = 16, it hits the limit, but it turns out that I still have plenty of CPU and RAM to spare and I want it to dynamically make use of that?