The startup culture at Posterous
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"Post-erous, posterous, smackerous... They're too busy putting in new features to care about stuff like that. They care about results, not pronunciations. That's the start-up way."
(Unless of course it's Garry Tan trying to correct you on it.)
A friend with a Russian accent just pronounced it hilariously today - something like Post-air-ee-ous. I think they should roll with that!