His two DNA sequencing companies (454 and Ion torrent) have both had what I would consider successful exits (solid to Roche and Life technologies respectively). But more importantly both products made their way into the hands of consumers (which is actually rare for DNA sequencing startups). However after acquisition both products failed to gain significant traction (Roche has just shelved 454).
He also engages in a certain amount of showmanship [1], which has as gained him some ridicule. I think he has to be respected to successfully executing in a market where most startups fizzle out though.
I hope this pans out though, it sounds awesome. I really hope this (and other research/medical device) technology makes its way into the hands of normal consumers (not just research labs/medical institutes).
[1] Oh and he has a scale model of Stonehenge in his back yard. http://clonehenge.com/2009/01/17/circle-of-life-connecticuts...