Note that reddit has rewritten at least once since the web.py rewrite. cf. https://news.ycombinator.com/item?id=51078

I recall reading a more scathing post from spez at one point about frustrations with web.py, but I don't seem to see it now. It may have been removed. In any case, Flask seems to be the inheritor of the "write webapps in Python" description.