> I use two of these on a laptop and desktop and I have never unplugged them; there's no reason to.
I use a Yubikey for ${WORK} and we are required to remove such tokens as soon as they have fulfilled their purpose. On pain of disciplinary action, as it is considered on par with leaving a password on a Post-it.
Otherwise there's no point in them as an additional security step in the event that the laptop is lost or stolen.