Personally, I get really frustrated when I spend 20 minutes writing out what I think is a respectful, thoughtful response with links to all of my sources, only to watch it get downvoted into oblivion only because (as far as I can tell) I'm conveying a minority opinion. It kills discussion and turns threads into echo chambers.
I turn on showdead and run my mouse over every grayed-out comment now. I think we'd have better discussions on divisive topics if people would save the downvote button for actual abuse instead of just indicating that they don't agree with you.