This is just my personal experience, but once you try to do certain things with Django, you start to butt heads with it. Django relies far too much on convention, and it shoehorns you into their tooling patterns.

I think the most exciting and flexible way to do things these days is with a collection of microservices. You can do feature work independently, test small isolable units of functionality, and achieve scale.That said, we could use cross-cutting libraries to make microservice implementation easier...