I hear this all the time, "argh, Deferreds are so hard to understand," as if there's some kind of magic going on in a Deferred. Deferreds are just a way to encapsulate two callbacks, one for errors and another for successful callbacks.
If you're writing any kind of significantly complicated asynchronous process, what is the difference between following a bunch of Deferreds and following a bunch of callbacks??
Asynchronous coding is hard. There's no framework that is going to make that go away. Diesel looks nice enough, but although it shows promise, there's not enough examples of hardcore usage to make a sufficient comparison. An asynchronous IO framework that has nothing but HTTP and echo examples doesn't even scratch the surface of the kinds of apps that require the advanced asynchrony available in Twisted.