A long but interesting read. The parallels with the mystery novels didn't make sense to me at first but then I understood that the evolution of such novels to greater complexity was being compared to the growing complexity of our understanding of alzheimer's disease.

I prefer to draw a comparison to CS. The Tau vs Amyloid camps are essentially defining two spaces where potential solutions may exist. It seems like the research is doing brute-force depth-first searches across potential solution spaces. Viewed in this manner, and given the lack of results, I wonder if a more comprehensive (breadth-first) approach might be more appropriate. Accounting for all sides of the puzzle rather than focusing on only one.

Undoubtedly more funding will be required in any case.