If you don't write Web stuff, you can ignore JS completely, and PureScript too.

If you prefer dynamically-typed languages, use them directly (JS, CoffeeScript, etc.)

If you prefer statically-typed languages, you must care about a dynamically-typed language, since every statically-typed language can be thought of as a dynamically-typed language + a machine-checkable safety net. For example, Haskell/ML/etc. are built on Lambda Calculus, C/FORTRAN/etc. are built on machine code. If you're programming for the Web, why not use JS as the dynamic part of your language (the "computational content")?