There are the ones who don't drink and don't have a problem with other people drinking. The people who are genuinely in this group, you don't even notice they don't drink. Drinkers have no quarrel with this group.
The second group are very vocal about their disapproval and are constantly telling you you shouldn't drink etc. They are irritating but can be ignored.
The third group thinks they are part of group 1, but they are actually closer to group 2. They never overtly tell you anything bad, but you get the constant sense that they are looking down on you. Drinkers don't like this group because they feel like they are constantly being judged, but not in a direct way they can challenge.
The three can probably be summed up by their response to the question, "Would you like a beer?"
Group 1: "No thanks, could I have a glass of water?"
Group 2: "No thanks, I'd rather not destroy my liver."
Group 3: "No thanks, I don't drink."
Group 4: "I would love to but I can’t. I’ll just have a glass of water (or a near-beer) instead"
More to the point, I've never even sought out, uh, non-sobriety, certainly the world's most popular avocation. I am apparently a mutant, and I definitely feel weird about it. I grew up in LA with no religious background, so it was decidedly countercultural.
Although when I went to Harvey Mudd, there was a definite teetotaling contingent among the self-experimentalists. There, if you brought up the Super Bowl, some would simply say "Spectator sports don't interest me." It was like that.
I am clearly in the minority of people in the world. But I really have no idea why alcohol is so popular.