It'll depend on who's on the other side of the hiring table.

I'm largely self-taught, but I have a CS degree from a good school. (It's a long story...the CS degree came after the self-teaching, for the most part.) If I were the hiring manager, someone who's self-taught would be a mild bonus: it shows initiative and passion. Other people think differently - some won't hire any without a degree, some would rather not hire someone without a degree, many don't care. You can to some extent choose who you work with and what they value by how you position yourself.