> It turns out that lots of people get their klotho levels increased as a side-effect of taking prescription forms of “activated” vitamin D (VDRAs) for chronic kidney disease (CKD). But there’s no reason to wait until you’re almost dying and need dialysis to start benefiting from this knowledge. Instead, this implies that taking something like 0.25 mcg/day of Calcitriol or 1 mcg/day of Paricalcitol right now for someone without the beneficial KL-VS variant of the KL gene might actually give a huge longevity and IQ boost.

Also, maybe exercise! http://mangans.blogspot.com/2014/07/klotho-increases-both-lo...

-- just reporting what I've read, I have no idea whether it works / is safe.