Arc is a pretty ambitious project, a language for 'the next hundred years' (see http://en.wikipedia.org/wiki/Arc_(programming_language) ).
Not sure about how many people actually use it though, HN is the only application that I'm aware of that uses it.
NewMogul
also uses the same software to run its site.
But this was about the language, not about the news.arc implementation.
Presumably you could write anything that you want in arc, if the language stands as an individual piece of code then 'HN' is sort of an example of what arc can do. So then the question is: has anybody written any other application using arc. And I'm not aware that that has happened.
edit:
So, after some digging I found this:
But yes, there are not so many projects using it to my Arc-forum-user knowledge too.
You need MzScheme 4 to run Arc.
See also http://arclanguage.org/install (installation instructions, but a bit out-of-date, it's for Arc 3.0) and http://arclanguage.org/item?id=10254 (Arc 3.1 announcement).