This reminds me of a comment I heard recently, I think from one of the presenters at TC50, where he said when referring to making money and what he wanted to do in 20 years, he said he'd still want to be working for the company, which was unlike what many of his peers would say (paraphrasing and possibly a quote of a quote from someone else). EDIT: I believe it was crowdfusion during their Q&A
http://www.techcrunch50.com/2009/crowd-fusion/ - Video is at the bottom
Either way, it seems like the twitter guys are happy where they are and this valuation should allow them to do what they want for some time to come. It puts them out of the reach of most in terms of being bought, especially since their value will most likely only increase in the coming years.