Hygiene hypothesis: difference in autoimmune diseases in Russia, Finland (2012)
ncbi.nlm.nih.gov
ncbi.nlm.nih.gov
The article "The Biodemography of Human Ageing" by James Vaupel,[3] originally published in the journal Nature in 2010, is a good current reference on the subject of how much life expectancy has improved at ALL ages in the developed world. Vaupel is one of the leading scholars on the demography of aging and how to adjust for time trends in life expectancy. His striking finding is "Humans are living longer than ever before. In fact, newborn children in high-income countries can expect to live to more than 100 years. Starting in the mid-1800s, human longevity has increased dramatically and life expectancy is increasing by an average of six hours a day."[4] An article in a series on Slate, "Why Are You Not Dead Yet? Life expectancy doubled in past 150 years. Here’s why"[5] Provides some of the background. Yep, perhaps in the clean modern world, our immune systems aren't challenged as much as they used to be, but we also get sick less often and live to much older ages with good health. Life expectancy at age 40, at age 60, and at even higher ages is still rising throughout the developed countries of the world.[6] That's a trade-off I will happily accept. My mom (who also has allergies) is eighty-one years old and still living independently and enjoying her favorite activities, and she has sisters and brothers older than she is who are still in good health. Girls born since 2000 in the developed world are more likely than not to reach the age of 100, with boys likely to enjoy lifespans almost as long. If that's what I have to put up with after living in a clean environment in my youth, I can deal with that.
[1] https://www.google.com/search?q=Finland+life+expectancy
[2] https://www.google.com/search?q=Russia+life+expectancy
[3] http://www.demographic-challenge.com/files/downloads/2eb51e2...
[4] http://www.prb.org/Journalists/Webcasts/2010/humanlongevity....
[5] http://www.slate.com/articles/health_and_science/science_of_...
[6] http://www.nature.com/scientificamerican/journal/v307/n3/box...
The problem with such nostalgic appeals is that they grossly underestimate modern science's ability to fix its own problems given enough time and resources. Immune system needs germs to practice on? What about a pill/lotion/inhaler/whatever that contains a variety of carefully selected and relatively harmless germs to give your immune system plenty of practice without risk of any life-threatening infection? You know, like a vaccine.
If the hygiene hypothesis becomes well-established, every pharmaceutical company will jump into the market with "germ pills". They could become as commonplace as multivitamins (though I hope they're more effective than today's multivitamins). Sooner or later, even FDA might begin to recommend a daily dose of mild pathogens for children. Problem solved, until we cause the next problem, wash, rinse, repeat.
Usually, the solution to science is more science.
They've already tried! Coronado Biosciences was testing a drug comprised of pig whipworm eggs for the treatment of Crohn's disease. Unfortunately it didn't work.
http://www.coronadobiosciences.com/research-development/hygi...
http://www.youtube.com/watch?v=CnmMNdiCz_s&list=PL4DDBE51446...
Edit: imagine, theoretically, if there is no germs and no need for immune system, would it mean additional biological resources available inside the human body for something else, like for bigger/better brain, etc...?
It would be tremendously risky as a species, and also very unfeasible considering how important microbes are to life, but you are correct in expecting an unused "feature" would likely be removed, as every "feature" has a cost. Much like cave fish that live in total darkness all their lives- their eyes disappear...
http://web.stanford.edu/group/siepr/cgi-bin/siepr/?q=system/...
Presumably, it's an issue with quantity. The ~20 mandatory vaccinations in West are simply a drop in the bucket compared to the number of different organism/antigens you'd be exposed to without modern sanitation.
Growing up on a farm probably gave us a bit more exposure, the only sicknesses I could recall really weren't, it was more like the breaking things as farms tend to be unforgiving
What has changed in recent decades and can be proven and measured: We are exposed to all kinds of chemicals that are known to have harmful effects, many of which did not exist until they were recently invented.
It seems to me this is a much more likely explanation of the outbreak in chronic health conditions and so-called "autoimmune diseases" in the developed world.
We have nasty stuff around still today, of course, but if there was a "dark age" of nasty chemicals it was fifty years ago.
The point being that you would expect our immune systems to be on the upswing if it was a chemicals problem.
Also, we don't really know what happens when parents who are contaminated with such chemicals have babies. I have heard from people who believe that is a major connection there: That what is relatively small amounts for an adult nevertheless have toxic effects in utero.
Plus, we use chemical fertilizers and pesticides in recent decades on an unprecedented scale.
I just really don't see where your argument holds water. It simply fails to fit with my understanding of what is going on in the world today. Also, fails to fit with my firsthand personal experience.
But thank you for replying.
In ever decreasing levels. There aren't any that remain at the same levels as decades ago.
we don't really know what happens when parents who are contaminated with such chemicals have babies
Right. So we can hardly draw conclusions, now can we? "We don't know what happens" isn't an argument that proves something happens.
I have heard from people who believe that is a major connection there
There are people out there who will tell you anything. "People" is not an authoritative source.
we use chemical fertilizers and pesticides in recent decades on an unprecedented scale.
Nope:
http://www.panna.org/blog/long-last-epa-releases-pesticide-u...
Oh, and looping way back to your comment about how gut flora is required to digest food- the presence of bacteria in the belly does not confer resistance to viruses. Your exposure to viruses is all from the environment.
Pesticide use in agriculture is down slightly, from 948 million pounds in 2000 to 877 million pounds in 2007. But that's only about 1% per year, and still close to a billion pounds of toxic chemicals intentionally introduced into the environment and our food supply each year.
So, just because it is down compared to some earlier period within the last few decades does not mean it is not historically unprecedented. I am talking on the scale of human history and how what we are doing chemically in recent decades is different from what was done for many thousands of years before that.
Some of the people I have talked to about such subjects have phd's and are published authors. I really don't think you are making a good faith effort to engage me here. So I think I shall bow out of this conversation at this point.
My point is that if "harmful chemical use" is down (even if only a little) over the last 50-70 years, then it seems unlikely said chemicals are the cause of an epidemic that appeared only a few decades ago and has been growing ever since. If they were the cause, you would expect the epidemic to start even earlier, and you certainly wouldn't expect the epidemic to grow as the chemical decreases.
A more dramatic example: imagine blaming the recent increase in autism diagnoses on alcohol. It's not entirely impossible, but it is suspicious. Alcohol has been around for millennium; if it is the cause, why is this only happening now?
I'm not saying this is proof of anything, but it calls your theory into question and I was curious if you had an explanation rather than simply saying "What you say doesn't agree with what I think so you must be wrong"
Having an (informed) opinion about something I have wrestled with a long time somehow makes me automagically wrong or bad or something? Why is that?
My point is that if "harmful chemical use" is down (even if only a little) over the last 50-70 years, then it seems unlikely said chemicals are the cause of an epidemic that appeared only a few decades ago and has been growing ever since. If they were the cause, you would expect the epidemic to start even earlier, and you certainly wouldn't expect the epidemic to grow as the chemical decreases.
A great many chemicals do not simply get rapidly dumped by the body once you stop being exposed. For some things, once you are exposed, you are toxic for the rest of your life unless something is done about it and doctors do not know a good way to fix it. So reducing exposure will not magically fix anything. Some things accumulate in the tissues over time. And some of those chemicals are out there in the general environment and people are still being exposed to them, even though they are no longer being used.
It is also well established fact that exposing a pregnant woman to certain things has a much bigger impact on the developing fetus than it would on an adult. That is hardly wild, random speculation on my part.
A more dramatic example: imagine blaming the recent increase in autism diagnoses on alcohol. It's not entirely impossible, but it is suspicious. Alcohol has been around for millennium; if it is the cause, why is this only happening now?
Yeah, that’s really funny since both my sons are autistic. I participated for a time on a list where one of the things being done to help autistic kids was chelation – ie removal of metals from the body. According to a PHD chemist (and published author) who was an active participant on the list, about 75% of autistic kids benefit from chelation. Metals are one of those known toxic chemicals that, for thousands of years, most ordinary people had relatively little exposure to but which are simply everywhere now. They are, logically, possibly very much a part of the problem here.
Once metals get into the tissues, the body does not automatically dump them. They tend to stay there for life, having toxic impacts on the immune function and brain function unless you carefully follow some very specific protocols to try to effectively remove them. Most medical doctors don’t know much about metals removal. It’s the alternative med community, where a PHD chemist did the math to work out the half-life of various chelators and also work out which chelators work for which metals, which has reasonably reliable answers on this topic. Of course, saying that is something that opens one up to automatic dismissal by a lot of folks who think the answers they know from peer reviewed journals (or whatever) are the only ones with any validity.
I'm not saying this is proof of anything, but it calls your theory into question and I was curious if you had an explanation rather than simply saying "What you say doesn't agree with what I think so you must be wrong"
If you were genuinely curious as to what I think, you could have indicated that much, much earlier instead of positioning yourself as merely shooting me down.
However as far as I know there is no connection to pesticides and health issues. People just think the word "pesticide" sounds scary.
Exposure to viruses is interesting, but what about vaccinations? And are we sure it's just viruses that affect the immune system? That doesn't seem very plausible.