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There's really no basis for putting a stake in the ground with web front-end frameworks right now. Based on recent history, the leading frameworks today will be YUI in 2-5 years. The best you can do is chose something that has a large community TODAY, get the most mileage you can out of it, and know that in 5 years or so you'll be scrapping most of it.

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Scrapping it may not be an option. If you have built hundreds of thousands of lines on top of a framework, the cost of a rewrite will dwarf the cost of maintaining the framework yourself. The trick is to choose a framework which you can maintain yourself (sources to every aspect of it which you understand well enough to maintain).

"If you have built hundreds of thousands of lines on top of a framework,"

Perhaps that wasn't the smartest architecture decision made. Now, don't compound it by rewriting it in the same deeply coupled way for the next shiny framework that sashay's by.

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