How do you refactor complex C code with myriad of macros? I think we should avoid writing code that having to seriously change its structure later. If we want to refactor, it should be minimal and manageable.

And if you mean seriously refactoring as in this article from Qt Creator: http://qt-project.org/doc/qtcreator-2.6/creator-editor-refac... that includes reformatting code, generating getter/setter or automatically detect and fix mistake for you, then no. I have never write such code in the first place that having to back later and I believe we should not fall into the use cases listed in that article.

My only use case for refactoring is to rename variable/function names.