Alright, some basics; Everything that has to access persistent information frequently is bound by disk/network/whatever IO, and web programming is no different. The reason why languages such as Python and Ruby are very viable options for this task is they are quite a lot abstracted away from bare metal to hasten the development process. The wait for IO is quite long compared to logic execution, so even though we are executing more instructions to get the same job done, the resulting overhead isn't very significant.
CPU-Bound computations are most definitely will execute faster in statically compiled languages such as C/C++, D, golang relative to interpreted languages but in the context of web programming this is not the case. Even though; if rendering HTML is such a big pain in the ass that it is slowing you down a lot you can always use a library that is implemented in a language that's fast, say C, and use its wrappings in your scripting language of choice. I am not sure about to what extent this is supported in other languages but I know you can do this in Python, heck you can do this in golang, even though it is a relatively new language [1]. I wonder how the author will move to C10M world by optimizing the wrong thing.