2400 hours worked + 260 hours commuting (US avg. is 25.5min - probably average higher in startup cities?) Let's say 17 waking hours (even though people who get 7 hours of sleep are proven to be less effective on a lot of fronts, it's certainly plenty common).
(edit: average hours worked/week in US for salaried workers is 46: http://www.prdaily.com/Main/Articles/Most_employed_Americans...)
2660 / 365*17 = 43%