Crispr: A game-changing genetic engineering technique

The original publication from 2012, in Science: http://www.sciencemag.org/content/337/6096/816.short

And the PDF: http://genetics.wustl.edu/bio5491/files/2013/03/Jinek-et.-al...

Wow - genetics has changed a lot since I finished my major in 2009 (as you would expect). Back then all the rage was siRNA and I had never heard of CRISPR despite many projects and a deep interest in bacterial and bacteriophage biochemistry