Unix and AS/400 are similar in that both can have uptime measured in years. Typically, with an AS/400, you unpack it and plug it in, and it just works. No drama.
Does it have a fancy UI? No. It's designed for line-of-business applications where there's heads-down data entry and reporting.
The AS/400 (I refuse to call it "iSeries") is one of the best parts of IBM. I am in dread of how Ginni will fuck up the division.