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Agreed, San Francisco is probably the worst place to be if you want to bootstrap.

I don't think so. There are so many early adopter, visionary customers here you can sign up on spec to pay you to develop your product.

Assuming your product appeals to the type of consumers or businesses that inhabit San Francisco.

What kind of businesses aren't in the Bay Area that you'd want to target?

Off the top of my head: large banks, insurance companies, automotive, military contracting, commodity agriculture & energy.

[Edit] Actually, this made me think, what precisely is in the bay area that I'd want to target. The obvious answer is companies whose major priorities are VC and/or other acquisition events and the ecosystem they create.

I would take SF over Antarctica.

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