https://gcc.gnu.org/bugzilla/show_bug.cgi?id=61407
Our team was on Yosemite but we all had to move back to Mavericks to actually do work.
Things I'm regularly using without issue: PyCharm, Thunderbird, Chrome, Firefox, Subline Text 2, and iTerm
However, WiFi with unreliable internet connection (like tethering over a phone) is very flaky – the WiFi connection itself keeps dropping.
Safari has trouble with some video streaming sites – YouTube at 1080p, Netflix. This can be because of my older hardware, but never had any issues with Mavericks. Also WebGL does not seem very performant. Chrome does all of this perfectly fine, though.
If you use virtualisation with VMWare Fusion, note you need 6.0.4 for it to work under Yosemite. 6.0.3 will not run.
The new dark mode menu bar and dock are nice, but there are some rendering issues. It seems 3rd party menu bar icons are also not compatible yet, so most will be invisible or broken in dark mode.
I use it full time for iOS dev and casual use and haven't had any showstoppers. I have my old mavericks install in a second partition and rarely reboot into it.
Otherwise it's in good shape for a beta OS that's still a couple of months from GM.
There's also something weird about Safari on Yosemite. Sometimes the tab bar would just hide completely and to get it back you'd have to reopen Safari. (The tab switcher and cmd-{ cmd-} would still work.)
Other than that, for node / homebrew / mongo etc everything's been fine.
And Photoshop CC and Lightroom 5.4 have been rock-solid for me.