Not saying any of it is easy to automate by a long shot. But that kind of innovation is going to be what is needed to propel the field forward.
Not saying any of it is easy to automate by a long shot. But that kind of innovation is going to be what is needed to propel the field forward.
More specifically, we are able to automate combinatorial gene assembly straight from a web app interfacing with a TECAN microfluidic liquid handling robot.
Here's a proof of concept with a simulator, but I've tested this in a live enviornment.
I don't see any microfluidics in that video, unless one of those reservoir blocks or plates is actually something else?
You know that's pretty far from really automating combinatorial gene assembly :p You need a lot more than a Tecan to do that kind of cloning; even just the assembly reaction (Gibson?), which is the simplest part is going to be better off in a thermocycler or incubator compared to a warmed deck block. Tecans are pretty unusable at volumes below 2-3 ul, too, so setting up the reaction isn't always straight forward, especially if you need to e.g., PCR fragments out for the assembly.
Transcriptic's API covers the rest of the devices: https://www.transcriptic.com/platform