> Though I believe that a degree of indirection is preserved on AMD64 to enable symbol interposition?

You really don't want symbol interdiction. You don't use it most of the time, and the rest of the time, you're just changing a call that looks like:

    foo(1, 2);

to

    (*g_foo)(1, 2);

Which do you think is faster? There's a reason everything on Android compiles with -Bsymbolic (which kills interdiction for calls between functions in the same module). You really should be compiling all your code with -Bsymbolic -fvisibility=hidden; explicitly export the symbols you want other modules to call.