I think a part of the answer is that if you have free form replication that isn't perfect, then sooner or later something is going to emerge from that goo that realises that it's just more efficient to eat the goo. Combine that self correcting cycle with hard limits imposed by nature (presumably they need to have a power source to make it work - the goo would start to die the minute it gets to a millimetre because of inaccessible sunlight. Then there is toxicity, what happens to the waste? Heat dissipation. Structural issues and other things...) and you have the recipe for a shorter sci-fi series than Firefly. (Dear Mark, today we succeeded in making self replicating nano-robots. They were exponentially multiplying within the petri dish and then they stayed in the petri dish, because apparently nano-robots are tastier than glass and metal. Doesn't matter though, we cracked open the crate of champagne anyway.)
Which is also an argument against von Neumann probes, btw. Perfect replication isn't possible, so sooner or later you are going to see a ton of weird errors accumulate to unpredictable behaviour... (perhaps a shark that goes around "eating" other probes?)