Phone screeners --- who barely count for anything in our process, but don't get me started on that --- might skim a resume just so they have something to start talking about.
Otherwise, our hiring process is resume-blind.
We bring people in directly out of school, from random line-of-business programming jobs all around the country, and from networking jobs for people who want to transfer into something more developer-y.
I should mention: our work is not easy. I can hold my own in an argument that says we're significantly more technical and significantly more sophisticated than the median Silicon Valley startup.
Resumes are worthless. Do not bother. If you're screening with resumes, you're doing something wrong.