In my opinion it is far better to secure a high salary and the free-time and autonomy to work on your own higher-risk pursuits, than it is to secure a low salary and share a tiny percentage of optionality and autonomy with others on a high-risk pursuit.
The only exception I'd make is when you're truly enamoured with a vision, a founder, prone to loneliness and need to belong, or don't wish to focus on your economic livelihood at all.
At the end of the day the likelihood is that the high-risk pay-off never comes. Just like almost everybody else you'll become old, have a family and want to be able to provide for them.