Why not? I have a Tenkeyless (no numpad) keyboard with mechanical switches that I use every day. It takes up a lot less space, and I don't find that I need a numpad (thanks to using a laptop keyboard for many years).
The Happy Hacking Keyboard Pro (https://elitekeyboards.com/products.php?sub=pfu_keyboards,hh...) is probably the ultimate geek keyboard, and it's a reduced layout mechanical KB.