"A $3.8 million Predator carrying a Hellfire missile cratered near Kandahar in January 2010 because the pilot did not realize she had been flying the aircraft upside-down." - how can this happen? Isn't the picture upside down on the screen?
The artificial horizon might not been working correctly as well.
Getting disoriented even on a real aircraft is not that hard. Sometimes even during constant turning the brain's accelerator resets and can interpret the turning as level flight.