100% agreed.
I'm from New York City but went to college in the 'Burgh, and while I do have an affinity for the place given the four years I spent there, I'd never choose to live there. It's a remarkably isolated city...
The last time Pittsburgh was a real, honest transit nexus was some 60-70 years ago for the Pennsylvania Railroad. While USAir had something of a hub at PIT, it's been tertiary to PHL and CLT since the company was called USAir, and then they pulled out very quickly after they were acquired by America West. For road travel, maybe it's a pass through city if you are starting in Philly and are driving to Cleveland, Detroit, or Chicago, but most of the traffic in the NE Corridor opts for I-80 to the north, which is much more direct and a much easier drive than the Turnpike.
Pittsburgh also doesn't have much of a metropolitan area surrounding it. The drop-off from downtown to rural is rather stark. And while there are indeed some nice neighborhoods (Shadyside and Squirrel Hill within the city... Fox Chapel and Wexford to name a few outside,) most of the inner suburbs have an, IMHO, outer-outer borough NYC feel to them (i.e. Bay Ridge or Bay Side, not Williamsburg or Park Slope.) There is practically no commuter belt, so you either really have to like the urban core, or the surrounding mountain towns.
So yes, it's an isolated city. Even Cleveland and Baltimore have more of a metro-urban feel to them in some respects. It's certainly not an issue for many who choose to live there, but it's always been my reason for staying away after college.