I love that TikZ lets you embed graphics right in your document without external dependencies on PDF figures, but I've never been able to build anything non-trivial without quite a lot of effort.
If the OmniGraffle people are listening, I've been buying your product every release since I think about 2003 or 2004. I would love to see clean, approximate TiKZ export (where possible with simple geometries) with janky, verbose PGF as a fallback option when an exact complicated reproduction is required.
TikZ is not different that LaTeX in general. It has a hard learning curve, but you gain long term on reuse, structure, versioning.
Also slides in Beamer are a mess at the beginning, but maintaining/sharing/co-working... I personally think it's way easier than with ppt.
$ nano mydoc.md ; pandoc -t latex -S -o mydoc.tex mydoc.md
Pandoc drastically reduces the initial learning curve for latex and beamer.That being said tikz was one of the packages I thought was noticeably absent from the nine listed packages. The other package that I would add was fontspec, in fact I was shocked to see microtype and not see fontspec mentioned next.
I usually try to not worry about fine-tuning at all until the document is done, otherwise the whole point of latex is lost to me.
EDIT: Forgot link to Crémer's guide: http://cremeronline.com/LaTeX/minimaltikz.pdf