One anecdote. My team had done some work with a contractor, who was blind, to do QA around accessibility features and screen reader compatibility, his specialty. He came into town for an all-hands meeting, and after a brief orientation to the physical layout of the office, was perfectly self-sufficient and resourceful. Until one point a day or two into his visit when he called me over to his desk asking for help. He was rather frustrated because his screen reader had completely stopped talking to him, even though he could feel from the fans that it was still on. He asked if I could see anything obviously wrong on his screen. I failed to suppress a bit of a chuckle as I realized the screen in front of him was the least accessible in all of Windows: a BSOD!